New clues to COPD linked to proteostasis imbalance caused by cigarette smoke

https://www.sciencedaily.com/releases/2016/06/160622115125.htm

Free radicals can reach the endoplasmic reticulum, a cellular organelle that is critical in manufacturing and transporting fats, steroids, hormones and various proteins, and alter its function by oxidizing and damaging its most abundant and crucial to protein folding chaperone, Protein Disulfide Isomerase (PDI).

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